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KMID : 0882420070730001039
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Korean Journal of Medicine
2007 Volume.73 No. 0 p.1039 ~ p.1044
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A case of isolated multiple lymph node involvement of Langerhans cell histiocytosis in an adult
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Lee Yune-Jeong
Kim Su-Yoen
Hong Sook-Hee
Woo In-Sook
Byeon Jae-Ho
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Abstract
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Langerhans cell histiocystosis or Histiocytosis X is characterized by the proliferation of Langerhans cells. The clinical manifestations vary from localized solitary lesion to multifocal unisystem disease (Hand-Schuller-Christian disease) or multifocal, multi-systemic disease (Letterer-Siwe disease). In unisystem disease, it usually involves bone or lung, but it is relatively unusual to involve the skin, pituitary/thalamus or lymph nodes. The clinical course also varies from spontaneous regression to a life-threatening event. A solitary bone lesion can be managed by surgical resection, local radiation therapy or both. However multi-systemic lesion, and especially extra skeletal disease, may require systemic chemotherapy, which is most commonly a vinblastine based regimen. We report here on a case of Langerhans cell histiocytosis in an older-age patient, and the patient presented with only multiple lymph node involvement. He responded well to combination chemotherapy.(Korean J Med 73:S1039-S1044, 2007)
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KEYWORD
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Langerhans cell histiocytosis, Lymph node, Chemotherapy
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